| Reaction Details |
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 | Report a problem with these data |
| Target | Protein kinase C beta type |
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| Ligand | BDBM50292434 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_481053 (CHEMBL997493) |
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| IC50 | >150000±n/a nM |
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| Citation |  Fujioka, T; Kashiwada, Y; Kilkuskie, RE; Cosentino, LM; Ballas, LM; Jiang, JB; Janzen, WP; Chen, IS; Lee, KH Anti-AIDS Agents, 11. Betulinic Acid and Platanic Acid as Anti-HIV Principles from Syzigium claviflorum, and the Anti-HIV Activity of Structurally Related Triterpenoids J Nat Prod57:243-247 (1994) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Protein kinase C beta type |
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| Name: | Protein kinase C beta type |
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| Synonyms: | KPCB_HUMAN | PKC alpha and beta-2 | PKC beta | PKC beta isoform 2 | PKCB | PRKCB | PRKCB1 | Protein Kinase C, beta II | Protein kinase C beta type | Protein kinase C beta type II (PRKCB2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 76873.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | The recombinant human PKC enzymes were
produced using a baculovirus expression system in SF9 cells
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| Residue: | 671 |
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| Sequence: | MADPAAGPPPSEGEESTVRFARKGALRQKNVHEVKNHKFTARFFKQPTFCSHCTDFIWGF
GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPASDDPRSKHKFKIHTYSSPTFCDHCGS
LLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGTDHTERRGRIYIQAHIDRDVLIVLVRDA
KNLVPMDPNGLSDPYVKLKLIPDPKSESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRL
SVEIWDWDLTSRNDFMGSLSFGISELQKASVDGWFKLLSQEEGEYFNVPVPPEGSEANEE
LRQKFERAKISQGTKVPEEKTTNTVSKFDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSE
RKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALPGKPPFLTQLHSCFQTMDRLYFVM
EYVNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHI
KIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAP
FEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPEGERDIKEHAFF
RYIDWEKLERKEIQPPYKPKARDKRDTSNFDKEFTRQPVELTPTDKLFIMNLDQNEFAGF
SYTNPEFVINV
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| BDBM50292434 |
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| n/a |
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| Name | BDBM50292434 |
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| Synonyms: | CHEMBL509422 | betulinic acid 28-O-carboxymethylmethylate |
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| Type | Small organic molecule |
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| Emp. Form. | C33H52O5 |
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| Mol. Mass. | 528.763 |
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| SMILES | COC(=O)COC(=O)[C@]12CC[C@H]([C@@H]1[C@H]1CC[C@@H]3[C@@]4(C)CC[C@H](O)C(C)(C)[C@@H]4CC[C@@]3(C)[C@]1(C)CC2)C(C)=C |r| |
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| Structure | 
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