Ki Summary

Reaction Details

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Target

Tyrosine-protein kinase transforming protein Abl

Ligand

BDBM50292481

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_506213 (CHEMBL942402)

IC50

20000±n/a nM

Citation

Chang, CJ; Geahlen, RL Protein-Tyrosine Kinase Inhibition: Mechanism-Based Discovery of Antitumor Agents J Nat Prod55:1529-1560 (1992) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Tyrosine-protein kinase transforming protein Abl

Name:

Tyrosine-protein kinase transforming protein Abl

Synonyms:

ABL | ABL_MLVAB | Tyrosine-protein kinase V-ABL

Type:

Enzyme

Mol. Mass.:

81895.89

Organism:

Abelson murine leukemia virus

Description:

P00521

Residue:

746

Sequence:

YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY
RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK
WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK
HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYL
EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN
KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRT
CRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKV
GLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEA
GGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPST
APAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAIS
RNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATA
SSGPAATQDFSKLLSSVKEISDIVRR

BDBM50292481

n/a

Name

BDBM50292481

Synonyms:

4-(2-nitrovinyl)phenyl 4-((S)-1-((S)-1-(2-aminoethylamino)-1-oxopropan-2-ylamino)-1-oxopropan-2-ylcarbamoyl)benzenesulfonate hydrochloride | CHEMBL488101

Type

Small organic molecule

Emp. Form.

C23H27N5O8S

Mol. Mass.

533.554

SMILES

CC(NC(=O)C(C)NC(=O)c1ccc(cc1)[S+]([O-])(=O)Oc1ccc(\C=C\[N+]([O-])=O)cc1)C(=O)NCCN

Structure