| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosine-protein kinase transforming protein Abl |
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| Ligand | BDBM50292485 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_506213 (CHEMBL942402) |
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| IC50 | 40000±n/a nM |
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| Citation |  Chang, CJ; Geahlen, RL Protein-Tyrosine Kinase Inhibition: Mechanism-Based Discovery of Antitumor Agents J Nat Prod55:1529-1560 (1992) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosine-protein kinase transforming protein Abl |
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| Name: | Tyrosine-protein kinase transforming protein Abl |
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| Synonyms: | ABL | ABL_MLVAB | Tyrosine-protein kinase V-ABL |
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| Type: | Enzyme |
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| Mol. Mass.: | 81895.89 |
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| Organism: | Abelson murine leukemia virus |
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| Description: | P00521 |
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| Residue: | 746 |
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| Sequence: | YITPVNSLEKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHY
RINTASDGKLYVSSESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDK
WEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIK
HPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVSAVVLLYMATQISSAMEYL
EKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYN
KFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRA
CWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKRGTRGGAGSMLQAPELPTKTRT
CRRAAEQKASPPSLTPKLLRRQVTASPSSGLSHKKEATKGSASGMGTPATAEPAPPSNKV
GLSKASSEEMRVRRHKHSSESPGRDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEA
GGPTKTKCTSLAMDAVNTDPTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPST
APAPSPLAGDQQPSSAAFIPLISTRVSLRKTRQPPERIASGTITKGVVLDSTEALCLAIS
RNSEQMASHSAVLEAGKNLYTFCVSYVDSIQQMRNKFAFREAINKLESNLRELQICPATA
SSGPAATQDFSKLLSSVKEISDIVRR
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| BDBM50292485 |
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| n/a |
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| Name | BDBM50292485 |
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| Synonyms: | (S)-2-((S)-2-(4-(4-(2-nitrovinyl)phenoxysulfonyl)benzamido)propanamido)propanoic acid | CHEMBL490775 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21N3O9S |
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| Mol. Mass. | 491.471 |
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| SMILES | CC(NC(=O)C(C)NC(=O)c1ccc(cc1)[S+]([O-])(=O)Oc1ccc(\C=C\[N+]([O-])=O)cc1)C(O)=O |
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| Structure | 
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