| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 3 |
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| Ligand | BDBM50292642 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_496612 (CHEMBL1003787) |
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| IC50 | 500±n/a nM |
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| Citation |  Bongartz, JP; Buntinx, M; Coesemans, E; Hermans, B; Lommen, GV; Wauwe, JV Synthesis and structure-activity relationship of benzetimide derivatives as human CXCR3 antagonists. Bioorg Med Chem Lett18:5819-23 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 3 |
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| Name: | C-X-C chemokine receptor type 3 |
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| Synonyms: | AAO92295.1 | C-X-C chemokine receptor type 3 | C-X-C chemokine receptor type 3 (CXCR3) | C-X-C chemokine receptor type 3 (CXCR3A) | CXCR3 | CXCR3A | CXCR3_HUMAN | GPR9 | chemokine (C-X-C motif) receptor 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 40665.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 368 |
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| Sequence: | MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALY
SLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFG
SGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCL
LFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILA
VLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAK
SVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSET
SEASYSGL
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| BDBM50292642 |
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| n/a |
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| Name | BDBM50292642 |
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| Synonyms: | (+/-)-1'-(4-bromobenzyl)-3-(pyridin-2-yl)-3,4'-bipiperidine-2,6-dione | CHEMBL496564 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H24BrN3O2 |
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| Mol. Mass. | 442.349 |
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| SMILES | Brc1ccc(CN2CCC(CC2)C2(CCC(=O)NC2=O)c2ccccn2)cc1 |
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| Structure | 
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