| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent protein deacetylase sirtuin-1 |
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| Ligand | BDBM50228364 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_495772 (CHEMBL1007891) |
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| Kd | 16200±n/a nM |
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| Citation |  Vu, CB; Bemis, JE; Disch, JS; Ng, PY; Nunes, JJ; Milne, JC; Carney, DP; Lynch, AV; Smith, JJ; Lavu, S; Lambert, PD; Gagne, DJ; Jirousek, MR; Schenk, S; Olefsky, JM; Perni, RB Discovery of imidazo[1,2-b]thiazole derivatives as novel SIRT1 activators. J Med Chem52:1275-83 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| NAD-dependent protein deacetylase sirtuin-1 |
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| Name: | NAD-dependent protein deacetylase sirtuin-1 |
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| Synonyms: | NAD-Dependent Deacetylase Sirtuin-1 | NAD-dependent deacetylase sirtuin 1 | NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR1_HUMAN | SIR2-like protein 1 | SIR2L1 | SIRT1 | Sirtuin 1 (SIRT1) | Sirtuin-1 (SIRT1) | hSIR2 |
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| Type: | Developmental protein; hydrolase |
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| Mol. Mass.: | 81626.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 747 |
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| Sequence: | MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREV
PAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNL
YDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRP
RIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDI
NTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIE
YFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRII
QCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPE
QFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLG
DCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSS
PERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDL
KNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSD
SEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTD
GDDQEAINEAISVKQEVTDMNYPSNKS
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| BDBM50228364 |
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| n/a |
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| Name | BDBM50228364 |
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| Synonyms: | 3,4,5-trimethoxy-N-(2-(3-(piperazin-1-ylmethyl)imidazo[2,1-b]thiazol-6-yl)phenyl)benzamide | CHEMBL254156 | SRT-1460 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29N5O4S |
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| Mol. Mass. | 507.605 |
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| SMILES | COc1cc(cc(OC)c1OC)C(=O)Nc1ccccc1-c1cn2c(CN3CCNCC3)csc2n1 |
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| Structure | 
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