| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
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| Ligand | BDBM8126 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_496923 (CHEMBL1002018) |
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| IC50 | 12±n/a nM |
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| Citation |  Stevens, KL; Reno, MJ; Alberti, JB; Price, DJ; Kane-Carson, LS; Knick, VB; Shewchuk, LM; Hassell, AM; Veal, JM; Davis, ST; Griffin, RJ; Peel, MR Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors. Bioorg Med Chem Lett18:5758-62 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 4 |
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| Name: | Cyclin-dependent kinase 4 |
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| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 33731.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11802 |
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| Residue: | 303 |
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| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
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| BDBM8126 |
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| n/a |
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| Name | BDBM8126 |
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| Synonyms: | N-phenyl-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-amine | pyrazolo[1,5-b]pyridazine deriv. 16 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12N6 |
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| Mol. Mass. | 288.3067 |
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| SMILES | N(c1ccccc1)c1nccc(n1)-c1cnn2ncccc12 |
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| Structure | 
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