Reaction Details |
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Target | Cyclin-dependent kinase 2 |
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Ligand | BDBM50293150 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_496926 (CHEMBL1002021) |
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IC50 | 4±n/a nM |
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Citation | Stevens, KL; Reno, MJ; Alberti, JB; Price, DJ; Kane-Carson, LS; Knick, VB; Shewchuk, LM; Hassell, AM; Veal, JM; Davis, ST; Griffin, RJ; Peel, MR Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors. Bioorg Med Chem Lett18:5758-62 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cyclin-dependent kinase 2 |
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Name: | Cyclin-dependent kinase 2 |
Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase |
Type: | Enzyme Subunit |
Mol. Mass.: | 33938.17 |
Organism: | Homo sapiens (Human) |
Description: | P24941 |
Residue: | 298 |
Sequence: | MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH
PNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHS
HRVLHRDLKPQNLLINTEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYY
STAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSF
PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL
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BDBM50293150 |
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n/a |
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Name | BDBM50293150 |
Synonyms: | CHEMBL468963 | D3RKN_26 | GSK screening, 38 | N-(4-(4-methylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-4-(pyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-amine | TCMDC-138687 |
Type | Small organic molecule |
Emp. Form. | C22H21F3N8 |
Mol. Mass. | 454.4509 |
SMILES | CN1CCN(CC1)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1C(F)(F)F |
Structure |
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