| Reaction Details |
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 | Report a problem with these data |
| Target | B2 bradykinin receptor |
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| Ligand | BDBM50074986 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_572638 (CHEMBL1026062) |
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| IC50 | 0.3±n/a nM |
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| Citation |  Gibson, C; Schnatbaum, K; Pfeifer, JR; Locardi, E; Paschke, M; Reimer, U; Richter, U; Scharn, D; Faussner, A; Tradler, T Novel small molecule bradykinin B2 receptor antagonists. J Med Chem52:4370-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B2 bradykinin receptor |
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| Name: | B2 bradykinin receptor |
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| Synonyms: | B2 bradykinin receptor | B2R | BDKRB2 | BK-2 receptor | BKRB2_CAVPO | Bradykinin B2 receptor |
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| Type: | n/a |
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| Mol. Mass.: | 42217.03 |
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| Organism: | Cavia porcellus |
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| Description: | n/a |
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| Residue: | 372 |
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| Sequence: | MFNITSQVSALNATLAQGNSCLDAEWWSWLNTIQAPFLWVLFVLAVLENIFVLSVFFLHK
SSCTVAEIYLGNLAVADLILAFGLPFWAITIANNFDWLFGEVLCRMVNTMIQMNMYSSIC
FLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCALLLSSPMLVFRTMKDYRDEGH
NVTACLIIYPSLTWQVFTNVLLNLVGFLLPLSIITFCTVQIMQVLRNNEMQKFKEIQTER
RATVLVLAVLLLFVVCWLPFQIGTFLDTLRLLGFLPGCWEHVIDLITQISSYLAYSNSCL
NPLVYVIVGKRFRKKSREVYHGLCRSGGCVSEPAQSENSMGTLRTSISVDRQIHKLQDWA
RSSSEGTPPGLL
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| BDBM50074986 |
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| n/a |
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| Name | BDBM50074986 |
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| Synonyms: | (E)-N-({[4-Chloro-2-cyano-3-(2-methyl-quinolin-8-yloxymethyl)-phenyl]-methyl-carbamoyl}-methyl)-3-(4-trifluoromethyl-phenyl)-acrylamide | CHEMBL325255 | N-(2-((4-chloro-2-cyano-3-((2-methylquinolin-8-yloxy)methyl)phenyl)(methyl)amino)-2-oxoethyl)-3-(4-(trifluoromethyl)phenyl)acrylamide |
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| Type | Small organic molecule |
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| Emp. Form. | C31H24ClF3N4O3 |
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| Mol. Mass. | 592.995 |
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| SMILES | CN(C(=O)CNC(=O)\C=C\c1ccc(cc1)C(F)(F)F)c1ccc(Cl)c(COc2cccc3ccc(C)nc23)c1C#N |
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| Structure | 
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