| Reaction Details |
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 | Report a problem with these data |
| Target | DNA (cytosine-5)-methyltransferase 3B |
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| Ligand | BDBM50294483 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_575566 (CHEMBL1036409) |
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| IC50 | 3000±n/a nM |
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| Citation |  Saavedra, OM; Isakovic, L; Llewellyn, DB; Zhan, L; Bernstein, N; Claridge, S; Raeppel, F; Vaisburg, A; Elowe, N; Petschner, AJ; Rahil, J; Beaulieu, N; MacLeod, AR; Delorme, D; Besterman, JM; Wahhab, A SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. Bioorg Med Chem Lett19:2747-51 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA (cytosine-5)-methyltransferase 3B |
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| Name: | DNA (cytosine-5)-methyltransferase 3B |
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| Synonyms: | DNM3B_HUMAN | DNMT3B |
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| Type: | PROTEIN |
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| Mol. Mass.: | 95771.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1473708 |
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| Residue: | 853 |
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| Sequence: | MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
HLFAPLKDYFACE
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| BDBM50294483 |
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| n/a |
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| Name | BDBM50294483 |
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| Synonyms: | 2-amino-4-(((2S,3S,4R,5R)-5-(7-amino-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl)methylthio)butanoic acid | CHEMBL552246 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H19N7O5S |
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| Mol. Mass. | 385.399 |
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| SMILES | NC(CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1nnc2c(N)ncnc12)C(O)=O |r| |
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| Structure | 
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