Reaction Details |
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Target | DNA (cytosine-5)-methyltransferase 3B |
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Ligand | BDBM50294495 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_575566 (CHEMBL1036409) |
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IC50 | 600±n/a nM |
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Citation | Saavedra, OM; Isakovic, L; Llewellyn, DB; Zhan, L; Bernstein, N; Claridge, S; Raeppel, F; Vaisburg, A; Elowe, N; Petschner, AJ; Rahil, J; Beaulieu, N; MacLeod, AR; Delorme, D; Besterman, JM; Wahhab, A SAR around (l)-S-adenosyl-l-homocysteine, an inhibitor of human DNA methyltransferase (DNMT) enzymes. Bioorg Med Chem Lett19:2747-51 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA (cytosine-5)-methyltransferase 3B |
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Name: | DNA (cytosine-5)-methyltransferase 3B |
Synonyms: | DNM3B_HUMAN | DNMT3B |
Type: | PROTEIN |
Mol. Mass.: | 95771.12 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1473708 |
Residue: | 853 |
Sequence: | MKGDTRHLNGEEDAGGREDSILVNGACSDQSSDSPPILEAIRTPEIRGRRSSSRLSKREV
SSLLSYTQDLTGDGDGEDGDGSDTPVMPKLFRETRTRSESPAVRTRNNNSVSSRERHRPS
PRSTRGRQGRNHVDESPVEFPATRSLRRRATASAGTPWPSPPSSYLTIDLTDDTEDTHGT
PQSSSTPYARLAQDSQQGGMESPQVEADSGDGDSSEYQDGKEFGIGDLVWGKIKGFSWWP
AMVVSWKATSKRQAMSGMRWVQWFGDGKFSEVSADKLVALGLFSQHFNLATFNKLVSYRK
AMYHALEKARVRAGKTFPSSPGDSLEDQLKPMLEWAHGGFKPTGIEGLKPNNTQPVVNKS
KVRRAGSRKLESRKYENKTRRRTADDSATSDYCPAPKRLKTNCYNNGKDRGDEDQSREQM
ASDVANNKSSLEDGCLSCGRKNPVSFHPLFEGGLCQTCRDRFLELFYMYDDDGYQSYCTV
CCEGRELLLCSNTSCCRCFCVECLEVLVGTGTAAEAKLQEPWSCYMCLPQRCHGVLRRRK
DWNVRLQAFFTSDTGLEYEAPKLYPAIPAARRRPIRVLSLFDGIATGYLVLKELGIKVGK
YVASEVCEESIAVGTVKHEGNIKYVNDVRNITKKNIEEWGPFDLVIGGSPCNDLSNVNPA
RKGLYEGTGRLFFEFYHLLNYSRPKEGDDRPFFWMFENVVAMKVGDKRDISRFLECNPVM
IDAIKVSAAHRARYFWGNLPGMNRPVIASKNDKLELQDCLEYNRIAKLKKVQTITTKSNS
IKQGKNQLFPVVMNGKEDVLWCTELERIFGFPVHYTDVSNMGRGARQKLLGRSWSVPVIR
HLFAPLKDYFACE
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BDBM50294495 |
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n/a |
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Name | BDBM50294495 |
Synonyms: | (2-amino-4-(((2S,3S,4R,5R)-5-(6-(2-(biphenyl-4-yl)ethylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylthio)butanoic acid) | 2-Amino-4-{(2S,3S,4R,5R)-5-[6-(2-biphenyl-4-yl-ethylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethylsulfanyl}-butyric acid | CHEMBL555352 |
Type | Small organic molecule |
Emp. Form. | C28H32N6O5S |
Mol. Mass. | 564.656 |
SMILES | NC(CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCCc3ccc(cc3)-c3ccccc3)ncnc12)C(O)=O |r| |
Structure |
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