Ki Summary

Reaction Details

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Target

Proto-oncogene Wnt-3

Ligand

BDBM50294832

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_576549 (CHEMBL1032002)

EC50

>25000±n/a nM

Citation

Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett19:3825-7 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Proto-oncogene Wnt-3

Name:

Proto-oncogene Wnt-3

Synonyms:

INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN

Type:

PROTEIN

Mol. Mass.:

39653.31

Organism:

Homo sapiens (Human)

Description:

ChEMBL_576549

Residue:

355

Sequence:

MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCR
NYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIAS
AGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRP
DARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDS
ASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTC
NVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK

BDBM50294832

n/a

Name

BDBM50294832

Synonyms:

4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-ylmethyl)-cyclohexanecarboxylic acid(4-methyl-quinolin-8-yl)-amide | CHEMBL561913

Type

Small organic molecule

Emp. Form.

C27H29N3O3

Mol. Mass.

443.5375

SMILES

Cc1ccnc2c(NC(=O)[C@H]3CC[C@H](CN4C(=O)[C@H]5[C@@H]6C[C@@H](C=C6)[C@H]5C4=O)CC3)cccc12 |r,wU:19.19,21.20,10.9,wD:13.13,18.17,24.26,c:22,(7.79,-38.19,;6.46,-37.4,;5.12,-38.16,;3.78,-37.38,;3.8,-35.83,;5.15,-35.08,;5.16,-33.53,;3.83,-32.74,;3.85,-31.2,;5.2,-30.45,;2.53,-30.42,;1.19,-31.17,;-.13,-30.39,;-.11,-28.84,;-1.44,-28.05,;-2.97,-28.05,;-3.88,-26.82,;-3.4,-25.35,;-5.34,-27.29,;-6.67,-26.52,;-6.28,-28.01,;-6.7,-29.49,;-8.01,-28.82,;-8.01,-27.28,;-5.35,-28.83,;-3.88,-29.31,;-3.41,-30.78,;1.23,-28.09,;2.56,-28.88,;6.51,-32.78,;7.83,-33.57,;7.81,-35.11,;6.47,-35.87,)|

Structure