Ki Summary

Reaction Details

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Target

Proto-oncogene Wnt-3

Ligand

BDBM50294833

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_576549 (CHEMBL1032002)

EC50

10000±n/a nM

Citation

Lu, J; Ma, Z; Hsieh, JC; Fan, CW; Chen, B; Longgood, JC; Williams, NS; Amatruda, JF; Lum, L; Chen, C Structure-activity relationship studies of small-molecule inhibitors of Wnt response. Bioorg Med Chem Lett19:3825-7 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Proto-oncogene Wnt-3

Name:

Proto-oncogene Wnt-3

Synonyms:

INT4 | Proto-oncogene protein Wnt-3 | WNT3 | WNT3_HUMAN

Type:

PROTEIN

Mol. Mass.:

39653.31

Organism:

Homo sapiens (Human)

Description:

ChEMBL_576549

Residue:

355

Sequence:

MEPHLLGLLLGLLLGGTRVLAGYPIWWSLALGQQYTSLGSQPLLCGSIPGLVPKQLRFCR
NYIEIMPSVAEGVKLGIQECQHQFRGRRWNCTTIDDSLAIFGPVLDKATRESAFVHAIAS
AGVAFAVTRSCAEGTSTICGCDSHHKGPPGEGWKWGGCSEDADFGVLVSREFADARENRP
DARSAMNKHNNEAGRTTILDHMHLKCKCHGLSGSCEVKTCWWAQPDFRAIGDFLKDKYDS
ASEMVVEKHRESRGWVETLRAKYSLFKPPTERDLVYYENSPNFCEPNPETGSFGTRDRTC
NVTSHGIDGCDLLCCGRGHNTRTEKRKEKCHCIFHWCCYVSCQECIRIYDVHTCK

BDBM50294833

n/a

Name

BDBM50294833

Synonyms:

4-((1R,2S,6R,7S)-3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]dec-8-en-4-ylmethyl)-cyclohexanecarboxylic acid(7-methyl-quinolin-8-yl)-amide | CHEMBL551968

Type

Small organic molecule

Emp. Form.

C27H29N3O3

Mol. Mass.

443.5375

SMILES

Cc1ccc2cccnc2c1NC(=O)[C@H]1CC[C@H](CN2C(=O)[C@H]3[C@@H]4C[C@@H](C=C4)[C@H]3C2=O)CC1 |r,wU:23.25,25.26,14.15,wD:17.19,22.23,28.32,c:28,(26.79,-33.52,;26.76,-35.06,;28.09,-35.86,;28.07,-37.4,;26.73,-38.15,;26.72,-39.69,;25.38,-40.45,;24.04,-39.66,;24.06,-38.12,;25.4,-37.36,;25.42,-35.81,;24.09,-35.03,;24.11,-33.49,;25.46,-32.73,;22.79,-32.7,;21.45,-33.45,;20.13,-32.67,;20.14,-31.12,;18.82,-30.33,;17.28,-30.34,;16.38,-29.1,;16.85,-27.63,;14.91,-29.58,;13.59,-28.81,;13.97,-30.29,;13.56,-31.77,;12.25,-31.11,;12.25,-29.57,;14.91,-31.12,;16.37,-31.59,;16.85,-33.06,;21.49,-30.37,;22.81,-31.16,)|

Structure