| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Neuromedin-B receptor |
|---|
| Ligand | BDBM50295234 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_577514 (CHEMBL1057866) |
|---|
| IC50 | 540±n/a nM |
|---|
| Citation |  Fu, J; Shuttleworth, SJ; Connors, RV; Chai, A; Coward, P Discovery and optimization of a novel Neuromedin B receptor antagonist. Bioorg Med Chem Lett19:4264-7 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Neuromedin-B receptor |
|---|
| Name: | Neuromedin-B receptor |
|---|
| Synonyms: | Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43447.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Bombesin 1 NMBR 0::P28336 |
|---|
| Residue: | 390 |
|---|
| Sequence: | MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLG
NIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIP
VIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAV
FSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLI
KSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSL
GHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAV
RMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
|
|
|
|---|
| BDBM50295234 |
|---|
| n/a |
|---|
| Name | BDBM50295234 |
|---|
| Synonyms: | 11'-(2-fluoro-6-(trifluoromethyl)phenyl)-8'-methyl-4',5',10',11'-tetrahydrospiro[cyclopentane-1,3'-dibenzo[b,e][1,4]diazepin]-1'(2'H)-one | CHEMBL550567 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H24F4N2O |
|---|
| Mol. Mass. | 444.4645 |
|---|
| SMILES | Cc1ccc2N=C3CC4(CCCC4)CC(=O)C3C(Nc2c1)c1c(F)cccc1C(F)(F)F |t:5| |
|---|
| Structure | 
|
|---|
Search and Browse
