| Reaction Details |
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 | Report a problem with these data |
| Target | Gastrin-releasing peptide receptor |
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| Ligand | BDBM50295236 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_577515 (CHEMBL1057867) |
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| IC50 | >10000±n/a nM |
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| Citation |  Fu, J; Shuttleworth, SJ; Connors, RV; Chai, A; Coward, P Discovery and optimization of a novel Neuromedin B receptor antagonist. Bioorg Med Chem Lett19:4264-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gastrin-releasing peptide receptor |
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| Name: | Gastrin-releasing peptide receptor |
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| Synonyms: | Bombesin 2 | GRP-R | GRP-preferring bombesin receptor | GRPR | GRPR_HUMAN | Gastrin releasing peptide receptor | Gastrin-releasing peptide receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43214.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Bombesin 2 GRPR 0::P30550 |
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| Residue: | 384 |
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| Sequence: | MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNIT
LIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQ
LTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSD
LHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQS
AYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLH
FVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTS
LKSTNPSVATFSLINGNICHERYV
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| BDBM50295236 |
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| n/a |
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| Name | BDBM50295236 |
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| Synonyms: | 11-(2-chloro-6-fluorophenyl)-3,3,8-trimethyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one | CHEMBL552189 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H22ClFN2O |
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| Mol. Mass. | 384.874 |
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| SMILES | Cc1ccc2N=C3CC(C)(C)CC(=O)C3C(Nc2c1)c1c(F)cccc1Cl |t:5| |
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| Structure | 
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