Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50295294 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_578027 (CHEMBL1064059) |
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IC50 | 0.320±n/a nM |
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Citation | Denhart, DJ; Deskus, JA; Ditta, JL; Gao, Q; Dalton King, H; Kozlowski, ES; Meng, Z; LaPaglia, MA; Mattson, GK; Molski, TF; Taber, MT; Lodge, NJ; Mattson, RJ; Macor, JE Conformationally restricted homotryptamines. Part 5: 3-(trans-2-aminomethylcyclopentyl)indoles as potent selective serotonin reuptake inhibitors. Bioorg Med Chem Lett19:4031-3 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70322.51 |
Organism: | Homo sapiens (Human) |
Description: | P31645 |
Residue: | 630 |
Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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BDBM50295294 |
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n/a |
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Name | BDBM50295294 |
Synonyms: | (+/-)-trans-3-(2-((dimethylamino)methyl)cyclopentyl)-1H-indole-5-carbonitrile | 3-((1S,2S)-2-((dimethylamino)methyl)cyclopentyl)-1H-indole-5-carbonitrile | CHEMBL552167 | trans-3-((1S,2S)-2-((dimethylamino)methyl)cyclopentyl)-1H-indole-5-carbonitrile |
Type | Small organic molecule |
Emp. Form. | C17H21N3 |
Mol. Mass. | 267.3687 |
SMILES | CN(C)C[C@H]1CCC[C@@H]1c1c[nH]c2ccc(cc12)C#N |r| |
Structure |
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