| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen phosphorylase, muscle form |
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| Ligand | BDBM50263826 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_578067 (CHEMBL1051629) |
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| Ki | 160±n/a nM |
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| Citation |  Nagy, V; Benltifa, M; Vidal, S; Berzsényi, E; Teilhet, C; Czifrák, K; Batta, G; Docsa, T; Gergely, P; Somsák, L; Praly, JP Glucose-based spiro-heterocycles as potent inhibitors of glycogen phosphorylase. Bioorg Med Chem17:5696-707 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen phosphorylase, muscle form |
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| Name: | Glycogen phosphorylase, muscle form |
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| Synonyms: | Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT |
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| Type: | Enzyme |
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| Mol. Mass.: | 97296.32 |
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| Organism: | Oryctolagus cuniculus (rabbit) |
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| Description: | Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. |
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| Residue: | 843 |
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| Sequence: | MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERL
DWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVV
PRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
RLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE
YVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
KIP
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| BDBM50263826 |
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| n/a |
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| Name | BDBM50263826 |
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| Synonyms: | (1S)-1,5-Anhydro-D-glucitol-spiro[1.5]-3-(2-naphthyl)-1,4,2-oxathiazole | (5S,7R,8S,9S,10R)-7-Hydroxymethyl-3-naphthalen-2-yl-1,6-dioxa-4-thia-2-aza-spiro[4.5]dec-2-ene-8,9,10-triol | CHEMBL490175 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H17NO6S |
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| Mol. Mass. | 363.385 |
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| SMILES | OC[C@H]1O[C@]2(ON=C(S2)c2ccc3ccccc3c2)[C@H](O)[C@@H](O)[C@@H]1O |r,c:6| |
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| Structure | 
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