| Reaction Details |
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 | Report a problem with these data |
| Target | Neuropeptide Y receptor type 2 |
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| Ligand | BDBM50423655 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_578231 (CHEMBL1051546) |
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| IC50 | 3.3±n/a nM |
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| Citation |  Lunniss, GE; Barnes, AA; Barton, N; Biagetti, M; Bianchi, F; Blowers, SM; Caberlotto, L; Emmons, A; Holmes, IP; Montanari, D; Norris, R; Walters, DJ; Watson, SP The identification and optimisation of novel and selective diamide neuropeptide Y Y2 receptor antagonists. Bioorg Med Chem Lett19:4022-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuropeptide Y receptor type 2 |
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| Name: | Neuropeptide Y receptor type 2 |
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| Synonyms: | NPY-Y2 | NPY-Y2 receptor | NPY2-R | NPY2R | NPY2R_HUMAN | Neuropeptide Y receptor type 2 | Y2 receptor | neuropeptide Y receptor Y2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 42734.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | NPY-Y2 NPY2R HUMAN::P49146 |
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| Residue: | 381 |
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| Sequence: | MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSI
ILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGP
VLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLA
SPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYT
RIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDL
KEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAK
KNLEVRKNSGPNDSFTEATNV
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| BDBM50423655 |
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| n/a |
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| Name | BDBM50423655 |
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| Synonyms: | CHEMBL2307889 |
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| Type | Small organic molecule |
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| Emp. Form. | C49H57N11O6 |
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| Mol. Mass. | 896.047 |
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| SMILES | [#7]\[#6](-[#7])=[#7]\[#6]-[#6]-[#6]-[#6@@H](-[#7]-[#6](=O)-[#6]C1([#6]-[#6](=O)-[#7]-2-[#6]-[#6]-[#7](-[#6]-[#6]-2)-[#6]-2-c3ccccc3-[#7]-[#6](=O)-c3ccccc-23)[#6]-[#6]-[#6]-[#6]1)-[#6](=O)-[#7]-[#6]-[#6]-n1c(=O)n(-c2ccccc2)n(-c2ccccc2)c1=O |r| |
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| Structure | 
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