| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-3 |
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| Ligand | BDBM50295957 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_578994 (CHEMBL1061443) |
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| Ki | 0.85±n/a nM |
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| Citation |  Gao, Y; Ravert, HT; Kuwabara, H; Xiao, Y; Endres, CJ; Hilton, J; Holt, DP; Kumar, A; Alexander, M; Wong, DF; Dannals, RF; Horti, AG Synthesis and biological evaluation of novel carbon-11 labeled pyridyl ethers: candidate ligands for in vivo imaging of alpha4beta2 nicotinic acetylcholine receptors (alpha4beta2-nAChRs) in the brain with positron emission tomography. Bioorg Med Chem17:4367-77 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-3 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-3 |
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| Synonyms: | ACHA3_RAT | Acra3 | Chrna3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 56995.52 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P04757 |
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| Residue: | 499 |
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| Sequence: | MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEV
SMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNN
ADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAK
IDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTI
NLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGE
YLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGDT
PKTRTFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSE
SVNAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILV
CILGTAGLFLQPLMARDDT
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| BDBM50295957 |
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| n/a |
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| Name | BDBM50295957 |
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| Synonyms: | 2-Chloro-3-(2-chloro-5-(pyridinyl)methoxy)-5-((1-methyl)-2-(R)-pyrrolidinyl)methoxy)pyridine | CHEMBL551062 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19Cl2N3O2 |
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| Mol. Mass. | 368.258 |
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| SMILES | CN1CCC[C@@H]1COc1cnc(Cl)c(OCc2ccc(Cl)nc2)c1 |r| |
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| Structure | 
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