| Reaction Details |
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 | Report a problem with these data |
| Target | Heat shock factor protein 1 |
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| Ligand | BDBM50296058 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_579378 (CHEMBL1063219) |
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| EC50 | 24700±n/a nM |
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| Citation |  Zhou, Y; Wei, L; Brady, TP; Murali Mohan Redddy, PS; Nguyen, T; Chen, J; Au, Q; Yoon, IS; Yip, G; Zhang, B; Barber, JR; Ng, SC Pyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione derivatives as novel small molecule chaperone amplifiers. Bioorg Med Chem Lett19:4303-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heat shock factor protein 1 |
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| Name: | Heat shock factor protein 1 |
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| Synonyms: | HSF1 | HSF1_HUMAN | HSTF1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57244.20 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1512556 |
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| Residue: | 529 |
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| Sequence: | MDLPVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKY
FKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVT
SVSTLKSEDIKIRQDSVTKLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHA
QQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLNDSGSAHSMPKYSRQFSLEHVHGSGPY
SAPSPAYSSSSLYAPDAVASSGPIISDITELAPASPMASPGGSIDERPLSSSPLVRVKEE
PPSPPQSPRVEEASPGRPSSVDTLLSPTALIDSILRESEPAPASVTALTDARGHTDTEGR
PPSPPPTSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLSSHGFSVDTSALLDLFSP
SVTVPDMSLPDLDSSLASIQELLSPQEPPRPPEAENSSPDSGKQLVHYTAQPLFLLDPGS
VDTGSNDLPVLFELGEGSYFSEGDGFAEDPTISLLTGSEPPKAKDPTVS
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| BDBM50296058 |
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| n/a |
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| Name | BDBM50296058 |
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| Synonyms: | 1-ethyl-6-methyl-5,7-dioxo-3-(1H-pyrrol-2-yl)-1,5,6,7-tetrahydropyrimido[5,4-e][1,2,4]triazine 4-oxide | CHEMBL550516 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H12N6O3 |
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| Mol. Mass. | 288.2621 |
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| SMILES | CCn1nc(-c2ccc[nH]2)[n+]([O-])c2c1nc(=O)n(C)c2=O |
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| Structure | 
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