| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxypeptidase B |
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| Ligand | BDBM50296418 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_580862 (CHEMBL1064194) |
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| Ki | 15000±n/a nM |
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| Citation |  Fernández, D; Avilés, FX; Vendrell, J A new type of five-membered heterocyclic inhibitors of basic metallocarboxypeptidases. Eur J Med Chem44:3266-71 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carboxypeptidase B |
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| Name: | Carboxypeptidase B |
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| Synonyms: | CBPB1_HUMAN | CPB | CPB1 | Carboxypeptidase B | PASP | PCPB | Pancreas-specific protein | Thrombin-activatable fibrinolysis (TAFI) |
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| Type: | Enzyme |
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| Mol. Mass.: | 47367.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15086 |
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| Residue: | 417 |
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| Sequence: | MLALLVLVTVALASAHHGGEHFEGEKVFRVNVEDENHINIIRELASTTQIDFWKPDSVTQ
IKPHSTVDFRVKAEDTVTVENVLKQNELQYKVLISNLRNVVEAQFDSRVRATGHSYEKYN
KWETIEAWTQQVATENPALISRSVIGTTFEGRAIYLLKVGKAGQNKPAIFMDCGFHAREW
ISPAFCQWFVREAVRTYGREIQVTELLDKLDFYVLPVLNIDGYIYTWTKSRFWRKTRSTH
TGSSCIGTDPNRNFDAGWCEIGASRNPCDETYCGPAAESEKETKALADFIRNKLSSIKAY
LTIHSYSQMMIYPYSYAYKLGENNAELNALAKATVKELASLHGTKYTYGPGATTIYPAAG
GSDDWAYDQGIRYSFTFELRDTGRYGFLLPESQIRATCEETFLAIKYVASYVLEHLY
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| BDBM50296418 |
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| n/a |
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| Name | BDBM50296418 |
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| Synonyms: | 2-(6,9-dimethyl-5H-[1,2,4]triazino[5,6-b]indol-3-ylthio)-1-(4-fluorophenyl)ethanone | CHEMBL559480 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15FN4OS |
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| Mol. Mass. | 366.412 |
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| SMILES | Cc1ccc(C)c2c3nnc(SCC(=O)c4ccc(F)cc4)nc3[nH]c12 |
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| Structure | 
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