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TargetNociceptin receptor
LigandBDBM50274461
Substrate/Competitorn/a
Meas. Tech.ChEMBL_582618 (CHEMBL1054181)
IC50 0.41±n/a nM
Citation Nishimura, H; Li, J; Isozaki, K; Okada, K; Matsushima, A; Nose, T; Costa, T; Shimohigashi, Y Discriminatory synergistic effect of Trp-substitutions in superagonist [(Arg/Lys)(14), (Arg/Lys)(15)]nociceptin on ORL1 receptor binding and activation. Bioorg Med Chem17:5683-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nociceptin receptor
Name:Nociceptin receptor
Synonyms:Nociceptin/Orphanin FQ, NOP receptor | Nociceptin/mu opioid receptor | OPRX_RAT | Oor | Oprl | Oprl1
Type:Enzyme Catalytic Domain
Mol. Mass.:40531.08
Organism:RAT
Description:Nociceptin/Orphanin FQ, NOP receptor 0 RAT::P35370
Residue:367
Sequence:
MESLFPAPYWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCI
GGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALC
KTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGV
PVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLR
GVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRF
CTALGYVNSCLNPILYAFLDENFKACFRKFCCASSLHREMQVSDRVRSIAKDVGLGCKTS
ETVPRPA
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  Blast E-value cutoff:
BDBM50274461
n/a
NameBDBM50274461
Synonyms:CHEMBL504587 | FGGFTGARKSARKWANQ
TypeSmall organic molecule
Emp. Form.C84H128N28O22
Mol. Mass.1882.0895
SMILESC[C@@H](O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(O)=O |r,wU:26.27,3.3,1.1,42.44,58.59,73.75,89.90,112.116,125.128,wD:7.15,47.48,67.68,78.79,98.99,117.120,(9.16,.66,;10.48,-.11,;11.83,.66,;10.48,-1.65,;9.16,-2.42,;7.82,-1.64,;7.82,-.1,;6.49,-2.41,;6.49,-3.95,;7.82,-4.73,;9.15,-3.96,;10.49,-4.73,;10.48,-6.27,;9.15,-7.04,;7.81,-6.27,;5.15,-1.64,;3.82,-2.41,;3.82,-3.95,;2.48,-1.64,;1.15,-2.4,;-.19,-1.63,;-.19,-.09,;-1.52,-2.4,;-2.86,-1.63,;-4.19,-2.4,;-4.19,-3.94,;-5.52,-1.63,;-6.86,-2.4,;-5.52,-.09,;-4.2,.69,;-2.86,-.09,;-1.52,.68,;-1.52,2.22,;-2.85,2.99,;-4.19,2.22,;11.83,-2.42,;11.83,-3.96,;13.16,-1.65,;14.49,-2.42,;15.82,-1.66,;15.82,-.12,;17.16,-2.43,;18.5,-1.65,;18.5,-.12,;19.83,-2.43,;19.83,-3.97,;21.16,-1.66,;22.5,-2.43,;22.5,-3.98,;23.83,-4.74,;23.83,-6.29,;25.16,-7.06,;25.16,-8.61,;23.83,-9.38,;26.5,-9.37,;23.83,-1.66,;23.83,-.12,;25.17,-2.43,;26.5,-1.67,;26.5,-.13,;27.84,.64,;27.84,2.18,;29.18,2.95,;29.18,4.49,;27.84,-2.44,;27.84,-3.98,;29.17,-1.67,;30.51,-2.44,;30.51,-3.98,;31.84,-4.76,;31.84,-1.67,;31.84,-.13,;33.18,-2.45,;34.51,-1.68,;34.51,-.14,;35.85,-2.45,;35.85,-4,;37.18,-1.68,;38.52,-2.45,;38.52,-4,;39.85,-4.77,;39.85,-6.31,;41.18,-7.08,;41.18,-8.62,;39.84,-9.4,;42.52,-9.39,;39.85,-1.69,;39.85,-.15,;41.19,-2.46,;42.52,-1.69,;42.52,-.15,;43.85,.63,;43.85,2.16,;45.19,2.94,;45.19,4.47,;43.85,-2.46,;43.85,-4,;45.19,-1.69,;46.53,-2.47,;46.53,-4.01,;47.86,-4.77,;49.26,-4.15,;50.29,-5.3,;49.52,-6.63,;49.99,-8.1,;48.96,-9.24,;47.45,-8.92,;46.98,-7.45,;48.02,-6.31,;47.86,-1.69,;47.86,-.15,;49.19,-2.46,;50.53,-1.7,;50.53,-.16,;51.86,-2.47,;51.86,-4.02,;53.19,-1.7,;54.53,-2.47,;54.53,-4.01,;55.87,-4.79,;57.2,-4.01,;55.87,-6.33,;55.87,-1.7,;55.87,-.17,;57.21,-2.48,;58.53,-1.71,;58.53,-.17,;59.87,.6,;59.87,2.14,;58.54,2.91,;61.21,2.91,;59.87,-2.48,;61.2,-1.71,;59.87,-4.02,)|
Structure
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