Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM50297088 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_581592 (CHEMBL1062479) |
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Ki | 4650±n/a nM |
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Citation | Fish, PV; Wakenhut, F; Ryckmans, T; Stobie, A Design, synthesis and evaluation of N-[(3S)-pyrrolidin-3-yl]benzamides as selective noradrenaline reuptake inhibitors: CNS penetration in a more polar template. Bioorg Med Chem Lett19:4579-83 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68497.11 |
Organism: | Homo sapiens (Human) |
Description: | Q01959 |
Residue: | 620 |
Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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BDBM50297088 |
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n/a |
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Name | BDBM50297088 |
Synonyms: | (S)-2-phenoxy-N-phenyl-N-(pyrrolidin-3-yl)benzamide | CHEMBL564935 |
Type | Small organic molecule |
Emp. Form. | C23H22N2O2 |
Mol. Mass. | 358.433 |
SMILES | O=C(N([C@H]1CCNC1)c1ccccc1)c1ccccc1Oc1ccccc1 |r| |
Structure |
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