| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cyclin-dependent kinase 4 |
|---|
| Ligand | BDBM59087 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_582879 (CHEMBL1051860) |
|---|
| IC50 | 550±n/a nM |
|---|
| Citation |  Aubry, C; Wilson, AJ; Emmerson, D; Murphy, E; Chan, YY; Dickens, MP; García, MD; Jenkins, PR; Mahale, S; Chaudhuri, B Fascaplysin-inspired diindolyls as selective inhibitors of CDK4/cyclin D1. Bioorg Med Chem17:6073-84 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cyclin-dependent kinase 4 |
|---|
| Name: | Cyclin-dependent kinase 4 |
|---|
| Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 |
|---|
| Type: | Enzyme Subunit |
|---|
| Mol. Mass.: | 33731.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11802 |
|---|
| Residue: | 303 |
|---|
| Sequence: | MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALL
RRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDL
MRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWY
RAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEG
NPE
|
|
|
|---|
| BDBM59087 |
|---|
| n/a |
|---|
| Name | BDBM59087 |
|---|
| Synonyms: | CHEMBL258765 | Fasca-plysi | Fascaplysin |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H11N2O |
|---|
| Mol. Mass. | 271.2922 |
|---|
| SMILES | O=C1c2ccccc2-[n+]2ccc3c([nH]c4ccccc34)c12 |
|---|
| Structure | 
|
|---|
Search and Browse
