Ki Summary

Reaction Details

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Target

Delta-type opioid receptor

Ligand

BDBM50297293

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_582960 (CHEMBL1055016)

IC50

344±n/a nM

Citation

Balboni, G; Trapella, C; Sasaki, Y; Ambo, A; Marczak, ED; Lazarus, LH; Salvadori, S Influence of the side chain next to C-terminal benzimidazole in opioid pseudopeptides containing the Dmt-Tic pharmacophore. J Med Chem52:5556-9 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Delta-type opioid receptor

Name:

Delta-type opioid receptor

Synonyms:

DOR-1 | K56 | MSL-2 | OPIATE Delta | OPRD_MOUSE | Opioid receptors; mu and delta | Oprd1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

40577.25

Organism:

MOUSE

Description:

P32300

Residue:

372

Sequence:

MELVPSARAELQSSPLVNLSDAFPSAFPSAGANASGSPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTQPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRTPCGRQEPGSLRRPRQATTRERVTAC
TPSDGPGGGAAA

BDBM50297293

n/a

Name

BDBM50297293

Synonyms:

(S)-1H-benzo[d]imidazol-2-yl 2-((S)-2-((S)-1-((S)-2-((S)-2-((S)-2-amino-3-(4-hydroxy-2,6-dimethylphenyl)propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamido)-3-(4-hydroxyphenyl)propanoyl)pyrrolidine-2-carboxamido)-3-phenylpropanamido)-3-phenylpropanoate | CHEMBL563304

Type

Small organic molecule

Emp. Form.

C60H62N8O8

Mol. Mass.

1023.1831

SMILES

Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)c1nc2ccccc2[nH]1 |r|

Structure