| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sphingosine kinase 1 |
|---|
| Ligand | BDBM50240721 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_590261 (CHEMBL1052796) |
|---|
| IC50 | 5700±n/a nM |
|---|
| Citation |  Xiang, Y; Asmussen, G; Booker, M; Hirth, B; Kane, JL; Liao, J; Noson, KD; Yee, C Discovery of novel sphingosine kinase 1 inhibitors. Bioorg Med Chem Lett19:6119-21 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sphingosine kinase 1 |
|---|
| Name: | Sphingosine kinase 1 |
|---|
| Synonyms: | SK1 | SPHK | SPHK1 | SPHK1_HUMAN | SPK | Sphingosine kinase 1 | Sphingosine kinase 1 (SPHK1) | Sphingosine kinase types 1 (SphK1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42521.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NYA1 |
|---|
| Residue: | 384 |
|---|
| Sequence: | MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEAEISFTLMLTERRNHA
RELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPLCSLPAGSGNALAASL
NHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFSVLSLAWGFIADVDLE
SEKYRRLGEMRFTLGTFLRLAALRTYRGRLAYLPVGRVGSKTPASPVVVQQGPVDAHLVP
LEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAAGVMHLFYVRAGVSRAMLL
RLFLAMEKGRHMEYECPYLVYVPVVAFRLEPKDGKGVFAVDGELMVSEAVQGQVHPNYFW
MVSGCVEPPPSWKPQQMPPPEEPL
|
|
|
|---|
| BDBM50240721 |
|---|
| n/a |
|---|
| Name | BDBM50240721 |
|---|
| Synonyms: | (E)-(2S,3R)-2-Dimethylamino-octadec-4-ene-1,3-diol | CHEMBL322333 | N,N-Dimethylsphingosine | N,N-dimethylspingosine | dimethylspingosine |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H41NO2 |
|---|
| Mol. Mass. | 327.545 |
|---|
| SMILES | CCCCCCCCCCCCC\C=C\[C@@H](O)[C@H](CO)N(C)C |r| |
|---|
| Structure | 
|
|---|
Search and Browse
