| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2a |
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| Ligand | BDBM50299700 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_588679 (CHEMBL1056089) |
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| Ki | 10400±n/a nM |
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| Citation |  Volpini, R; Buccioni, M; Dal Ben, D; Lambertucci, C; Lammi, C; Marucci, G; Ramadori, AT; Klotz, KN; Cristalli, G Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor. J Med Chem52:7897-900 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2a |
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| Name: | Adenosine receptor A2a |
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| Synonyms: | A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44716.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29274 |
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| Residue: | 412 |
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| Sequence: | MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI
PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR
AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF
NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG
LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR
KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG
YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
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| BDBM50299700 |
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| n/a |
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| Name | BDBM50299700 |
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| Synonyms: | (2S,3S,4R,5R)-3,4-dihydroxy-5-(6-(methoxyamino)-2-((4-methoxyphenyl)ethynyl)-9H-purin-9-yl)-N-methyltetrahydrofuran-2-carboxamide | CHEMBL573950 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H22N6O6 |
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| Mol. Mass. | 454.436 |
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| SMILES | CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NOC)nc(nc12)C#Cc1ccc(OC)cc1 |r| |
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| Structure | 
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