| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Non-lysosomal glucosylceramidase |
|---|
| Ligand | BDBM50299753 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_589172 (CHEMBL1040323) |
|---|
| IC50 | >1000000±n/a nM |
|---|
| Citation |  Risseeuw, MD; van den Berg, RJ; Donker-Koopman, WE; van der Marel, GA; Aerts, JM; Overhand, M; Overkleeft, HS Synthesis and evaluation of D-gluco-pyranocyclopropyl amines as potential glucosidase inhibitors. Bioorg Med Chem Lett19:6600-3 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Non-lysosomal glucosylceramidase |
|---|
| Name: | Non-lysosomal glucosylceramidase |
|---|
| Synonyms: | Beta-glucosidase | GBA2 | GBA2_HUMAN | KIAA1605 | SPG46 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 104639.04 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1435476 |
|---|
| Residue: | 927 |
|---|
| Sequence: | MGTQDPGNMGTGVPASEQISCAKEDPQVYCPEETGGTKDVQVTDCKSPEDSRPPKETDCC
NPEDSGQLMVSYEGKAMGYQVPPFGWRICLAHEFTEKRKPFQANNVSLSNMIKHIGMGLR
YLQWWYRKTHVEKKTPFIDMINSVPLRQIYGCPLGGIGGGTITRGWRGQFCRWQLNPGMY
QHRTVIADQFTVCLRREGQTVYQQVLSLERPSVLRSWNWGLCGYFAFYHALYPRAWTVYQ
LPGQNVTLTCRQITPILPHDYQDSSLPVGVFVWDVENEGDEALDVSIMFSMRNGLGGGDD
APGGLWNEPFCLERSGETVRGLLLHHPTLPNPYTMAVAARVTAATTVTHITAFDPDSTGQ
QVWQDLLQDGQLDSPTGQSTPTQKGVGIAGAVCVSSKLRPRGQCRLEFSLAWDMPRIMFG
AKGQVHYRRYTRFFGQDGDAAPALSHYALCRYAEWEERISAWQSPVLDDRSLPAWYKSAL
FNELYFLADGGTVWLEVLEDSLPEELGRNMCHLRPTLRDYGRFGYLEGQEYRMYNTYDVH
FYASFALIMLWPKLELSLQYDMALATLREDLTRRRYLMSGVMAPVKRRNVIPHDIGDPDD
EPWLRVNAYLIHDTADWKDLNLKFVLQVYRDYYLTGDQNFLKDMWPVCLAVMESEMKFDK
DHDGLIENGGYADQTYDGWVTTGPSAYCGGLWLAAVAVMVQMAALCGAQDIQDKFSSILS
RGQEAYERLLWNGRYYNYDSSSRPQSRSVMSDQCAGQWFLKACGLGEGDTEVFPTQHVVR
ALQTIFELNVQAFAGGAMGAVNGMQPHGVPDKSSVQSDEVWVGVVYGLAATMIQEGLTWE
GFQTAEGCYRTVWERLGLAFQTPEAYCQQRVFRSLAYMRPLSIWAMQLALQQQQHKKASW
PKVKQGTGLRTGPMFGPKEAMANLSPE
|
|
|
|---|
| BDBM50299753 |
|---|
| n/a |
|---|
| Name | BDBM50299753 |
|---|
| Synonyms: | CHEMBL584580 | N-((1S,3R,4S,5R,6R,7S)-4,5-Dihydroxy-3-(hydroxymethyl)-2-oxabicyclo[4.1.0]heptan-7-yl)butyramide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H19NO5 |
|---|
| Mol. Mass. | 245.2723 |
|---|
| SMILES | CCCC(=O)N[C@@H]1[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@@H]12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
