Ki Summary

Reaction Details

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Target

Delta-type opioid receptor

Ligand

BDBM50300359

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_591213 (CHEMBL1058519)

IC50

97±n/a nM

Citation

Sinha, B; Cao, Z; Murray, TF; Aldrich, JV Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors. J Med Chem52:7372-5 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Delta-type opioid receptor

Name:

Delta-type opioid receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

40382.98

Organism:

Homo sapiens (Human)

Description:

Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.

Residue:

372

Sequence:

MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA

BDBM50300359

n/a

Name

BDBM50300359

Synonyms:

(S)-2-((S)-1-((2S,8S,11R,14S)-14-amino-8-benzyl-11-(4-(diisothiocyanatoamino)butyl)-2-(4-hydroxybenzyl)-15-(4-hydroxyphenyl)-4,7,10,13-tetraoxo-3,6,9,12-tetraazapentadecane)pyrrolidine-2-carboxamido)-3-hydroxypropanoic acid | CHEMBL584995

Type

Small organic molecule

Emp. Form.

C45H54N10O11S2

Mol. Mass.

975.101

SMILES

N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](CCCCN(N=C=S)N=C=S)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O |r|

Structure