| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histone acetyltransferase KAT2B |
|---|
| Ligand | BDBM50300415 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_591957 (CHEMBL1047520) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Ghizzoni, M; Haisma, HJ; Dekker, FJ Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase. Eur J Med Chem44:4855-61 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histone acetyltransferase KAT2B |
|---|
| Name: | Histone acetyltransferase KAT2B |
|---|
| Synonyms: | Histone acetyltransferase KAT2A/KAT2B | Histone acetyltransferase PCAF | KAT2B | KAT2B_HUMAN | PCAF |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 93045.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1502838 |
|---|
| Residue: | 832 |
|---|
| Sequence: | MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAA
AGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTP
PRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKE
RQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPR
YETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQ
NSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSG
LEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSA
RDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFD
PKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH
DILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFS
VIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSK
EPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNR
YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
|
|
|
|---|
| BDBM50300415 |
|---|
| n/a |
|---|
| Name | BDBM50300415 |
|---|
| Synonyms: | CHEMBL575673 | Methyl 3-[4-chloro-5-(dodecylthio)-1-oxido-3-oxoisothiazol-2(3H)-yl]propanoate |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H32ClNO4S2 |
|---|
| Mol. Mass. | 438.045 |
|---|
| SMILES | CCCCCCCCCCCCSc1c(Cl)c(=O)n(CCC(=O)OC)s1=O |
|---|
| Structure | 
|
|---|
Search and Browse
