| Reaction Details |
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 | Report a problem with these data |
| Target | Histone acetyltransferase KAT2B |
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| Ligand | BDBM50300425 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_591957 (CHEMBL1047520) |
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| IC50 | 2600±n/a nM |
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| Citation |  Ghizzoni, M; Haisma, HJ; Dekker, FJ Reactivity of isothiazolones and isothiazolone-1-oxides in the inhibition of the PCAF histone acetyltransferase. Eur J Med Chem44:4855-61 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone acetyltransferase KAT2B |
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| Name: | Histone acetyltransferase KAT2B |
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| Synonyms: | Histone acetyltransferase KAT2A/KAT2B | Histone acetyltransferase PCAF | KAT2B | KAT2B_HUMAN | PCAF |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93045.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1502838 |
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| Residue: | 832 |
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| Sequence: | MSEAGGAGPGGCGAGAGAGAGPGALPPQPAALPPAPPQGSPCAAAAGGSGACGPATAVAA
AGTAEGPGGGGSARIAVKKAQLRSAPRAKKLEKLGVYSACKAEESCKCNGWKNPNPSPTP
PRADLQQIIVSLTESCRSCSHALAAHVSHLENVSEEEMNRLLGIVLDVEYLFTCVHKEED
ADTKQVYFYLFKLLRKSILQRGKPVVEGSLEKKPPFEKPSIEQGVNNFVQYKFSHLPAKE
RQTIVELAKMFLNRINYWHLEAPSQRRLRSPNDDISGYKENYTRWLCYCNVPQFCDSLPR
YETTQVFGRTLLRSVFTVMRRQLLEQARQEKDKLPLEKRTLILTHFPKFLSMLEEEVYSQ
NSPIWDQDFLSASSRTSQLGIQTVINPPPVAGTISYNSTSSSLEQPNAGSSSPACKASSG
LEANPGEKRKMTDSHVLEEAKKPRVMGDIPMELINEVMSTITDPAAMLGPETNFLSAHSA
RDEAARLEERRGVIEFHVVGNSLNQKPNKKILMWLVGLQNVFSHQLPRMPKEYITRLVFD
PKHKTLALIKDGRVIGGICFRMFPSQGFTEIVFCAVTSNEQVKGYGTHLMNHLKEYHIKH
DILNFLTYADEYAIGYFKKQGFSKEIKIPKTKYVGYIKDYEGATLMGCELNPRIPYTEFS
VIIKKQKEIIKKLIERKQAQIRKVYPGLSCFKDGVRQIPIESIPGIRETGWKPSGKEKSK
EPRDPDQLYSTLKSILQQVKSHQSAWPFMEPVKRTEAPGYYEVIRFPMDLKTMSERLKNR
YYVSKKLFMADLQRVFTNCKEYNPPESEYYKCANILEKFFFSKIKEAGLIDK
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| BDBM50300425 |
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| n/a |
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| Name | BDBM50300425 |
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| Synonyms: | CHEMBL573028 | Methyl 3-(4,5-dichloro-3-oxoisothiazol-2(3H)-yl)propanoate |
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| Type | Small organic molecule |
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| Emp. Form. | C7H7Cl2NO3S |
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| Mol. Mass. | 256.106 |
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| SMILES | COC(=O)CCn1sc(Cl)c(Cl)c1=O |
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| Structure | 
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