| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50207561 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_592003 (CHEMBL1050118) |
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| IC50 | 66000±n/a nM |
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| Citation |  Tessier, P; Smil, DV; Wahhab, A; Leit, S; Rahil, J; Li, Z; Déziel, R; Besterman, JM Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. Bioorg Med Chem Lett19:5684-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50207561 |
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| n/a |
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| Name | BDBM50207561 |
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| Synonyms: | CHEMBL396097 | Class IIa HDAC inhibitor, Compound 6 | N-hydroxy-2,2-diphenylacetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13NO2 |
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| Mol. Mass. | 227.2585 |
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| SMILES | ONC(=O)C(c1ccccc1)c1ccccc1 |
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| Structure | 
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