Reaction Details |
| Report a problem with these data |
Target | Macrophage metalloelastase |
---|
Ligand | BDBM50300477 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_592283 (CHEMBL1045857) |
---|
IC50 | 54400±n/a nM |
---|
Citation | Holmes, IP; Gaines, S; Watson, SP; Lorthioir, O; Walker, A; Baddeley, SJ; Herbert, S; Egan, D; Convery, MA; Singh, OM; Gross, JW; Strelow, JM; Smith, RH; Amour, AJ; Brown, D; Martin, SL The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett19:5760-3 (2009) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Macrophage metalloelastase |
---|
Name: | Macrophage metalloelastase |
Synonyms: | HME | MMP12 | MMP12_HUMAN | Matrix metalloproteinase 12 | Matrix metalloproteinase-12 (MMP 12) | Matrix metalloproteinase-12 (MMP-12) | Matrix metalloproteinase-12 (MMP12) | Matrix metalloproteinases 12 (MMP-12) |
Type: | Enzyme |
Mol. Mass.: | 54012.99 |
Organism: | Homo sapiens (Human) |
Description: | P39900 |
Residue: | 470 |
Sequence: | MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLM
KEKIQEMQHFLGLKVTGQLDTSTLEMMHAPRCGVPDVHHFREMPGGPVWRKHYITYRINN
YTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDFHAFDGKGGI
LAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTY
KYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGNKIFF
FKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRP
EPNYPKSIHSFGFPNFVKKIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITK
NFQGIGPKIDAVFYSKNKYYYFFQGSNQFEYDFLLQRITKTLKSNSWFGC
|
|
|
BDBM50300477 |
---|
n/a |
---|
Name | BDBM50300477 |
Synonyms: | 3-acetoxy-5-(biphenyl-4-yl)pentanoic acid | CHEMBL574445 |
Type | Small organic molecule |
Emp. Form. | C19H20O4 |
Mol. Mass. | 312.3597 |
SMILES | CC(=O)OC(CCc1ccc(cc1)-c1ccccc1)CC(O)=O |
Structure |
|