| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin L1 |
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| Ligand | BDBM50300779 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_591546 |
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| IC50 | 900±n/a nM |
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| Citation |  Mallari JP; Shelat AA; Kosinski A; Caffrey CR; Connelly M; Zhu F; McKerrow JH; Guy RK Structure-guided development of selective TbcatB inhibitors. J Med Chem 52:6489-93 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin L1 |
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| Name: | Cathepsin (L and K) |
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| Synonyms: | Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM50300779 |
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| n/a |
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| Name | BDBM50300779 |
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| Synonyms: | 9-(3-hydroxypropyl)-6-((2'-isopropylbiphenyl-3-yl)methylamino)-9H-purine-2-carbonitrile | CHEMBL569883 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26N6O |
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| Mol. Mass. | 426.5135 |
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| SMILES | CC(C)c1ccccc1-c1cccc(CNc2nc(nc3n(CCCO)cnc23)C#N)c1 |
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| Structure | 
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