| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Transporter |
|---|
| Ligand | BDBM50301211 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_598777 (CHEMBL1042017) |
|---|
| Ki | 8.4±n/a nM |
|---|
| Citation |  Jobson, NK; Crawford, AR; Dewar, D; Pimlott, SL; Sutherland, A Design and synthesis of (2R,3S)-iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorg Med Chem Lett19:4996-8 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Transporter |
|---|
| Name: | Transporter |
|---|
| Synonyms: | NE transporter | NET | Norepinephrine transporter(NET) |
|---|
| Type: | Multi-pass membrane protein |
|---|
| Mol. Mass.: | 69236.90 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Q63380 |
|---|
| Residue: | 617 |
|---|
| Sequence: | MLLARMKPQVQPELGGADQLPEQPLRPCKTADLLVVKERNGVQCLLASQDGDAQPRETWG
KEIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
|
|
|
|---|
| BDBM50301211 |
|---|
| n/a |
|---|
| Name | BDBM50301211 |
|---|
| Synonyms: | (2R,3S)-2-[(2-Iodophenoxy)phenylmethyl]morpholine | CHEMBL568336 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H18INO2 |
|---|
| Mol. Mass. | 395.2348 |
|---|
| SMILES | Ic1ccccc1O[C@H]([C@H]1CNCCO1)c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
