| Reaction Details |
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 | Report a problem with these data |
| Target | D(1A) dopamine receptor |
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| Ligand | BDBM50301262 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599093 (CHEMBL1047148) |
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| Ki | 154±n/a nM |
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| Citation |  Zhu, Z; Sun, ZY; Ye, Y; McKittrick, B; Greenlee, W; Czarniecki, M; Fawzi, A; Zhang, H; Lachowicz, JE Design and discovery of 1,3-benzodiazepines as novel dopamine antagonists. Bioorg Med Chem Lett19:5218-21 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(1A) dopamine receptor |
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| Name: | D(1A) dopamine receptor |
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| Synonyms: | DA D1 receptor | DOPAMINE D1 | DRD1 | DRD1_HUMAN | Dopamine D1 receptor | Dopamine D1 receptor (D1R) | Dopamine D1A |
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| Type: | Enzyme |
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| Mol. Mass.: | 49303.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21728 |
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| Residue: | 446 |
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| Sequence: | MRTLNTSAMDGTGLVVERDFSVRILTACFLSLLILSTLLGNTLVCAAVIRFRHLRSKVTN
FFVISLAVSDLLVAVLVMPWKAVAEIAGFWPFGSFCNIWVAFDIMCSTASILNLCVISVD
RYWAISSPFRYERKMTPKAAFILISVAWTLSVLISFIPVQLSWHKAKPTSPSDGNATSLA
ETIDNCDSSLSRTYAISSSVISFYIPVAIMIVTYTRIYRIAQKQIRRIAALERAAVHAKN
CQTTTGNGKPVECSQPESSFKMSFKRETKVLKTLSVIMGVFVCCWLPFFILNCILPFCGS
GETQPFCIDSNTFDVFVWFGWANSSLNPIIYAFNADFRKAFSTLLGCYRLCPATNNAIET
VSINNNGAAMFSSHHEPRGSISKECNLVYLIPHAVGSSEDLKKEEAAGIARPLEKLSPAL
SVILDYDTDVSLEKIQPITQNGQHPT
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| BDBM50301262 |
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| n/a |
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| Name | BDBM50301262 |
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| Synonyms: | 7-chloro-2-(4-(dimethylamino)styryl)-1-phenyl-4,5-dihydro-1H-benzo[d][1,3]diazepin-8-ol | CHEMBL583672 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H24ClN3O |
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| Mol. Mass. | 417.931 |
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| SMILES | CN(C)c1ccc(\C=C\C2=NCCc3cc(Cl)c(O)cc3N2c2ccccc2)cc1 |t:9| |
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| Structure | 
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