| Reaction Details |
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 | Report a problem with these data |
| Target | Transthyretin |
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| Ligand | BDBM10304 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_599726 (CHEMBL1048170) |
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| IC50 | 6300±n/a nM |
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| Citation |  González, A; Quirante, J; Nieto, J; Almeida, MR; Saraiva, MJ; Planas, A; Arsequell, G; Valencia, G Isatin derivatives, a novel class of transthyretin fibrillogenesis inhibitors. Bioorg Med Chem Lett19:5270-3 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Transthyretin |
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| Name: | Transthyretin |
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| Synonyms: | ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 15884.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P02766 |
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| Residue: | 147 |
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| Sequence: | MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDT
WEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDS
GPRRYTIAALLSPYSYSTTAVVTNPKE
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| BDBM10304 |
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| n/a |
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| Name | BDBM10304 |
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| Synonyms: | 1-methyl-2,3-dihydro-1H-indole-2,3-dione | CHEMBL60569 | Isatin analog 8 | N‐methylindol‐2,3‐dione (Compound 2) |
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| Type | Small organic molecule |
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| Emp. Form. | C9H7NO2 |
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| Mol. Mass. | 161.1574 |
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| SMILES | CN1C(=O)C(=O)c2ccccc12 |
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| Structure | 
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