| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-7 |
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| Ligand | BDBM50036166 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_595288 (CHEMBL1047082) |
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| Ki | 140±n/a nM |
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| Citation |  Grazioso, G; Pomè, DY; Matera, C; Frigerio, F; Pucci, L; Gotti, C; Dallanoce, C; De Amici, M Design of novel alpha7-subtype-preferring nicotinic acetylcholine receptor agonists: application of docking and MM-PBSA computational approaches, synthetic and pharmacological studies. Bioorg Med Chem Lett19:6353-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-7 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-7 |
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| Synonyms: | ACHA7_RAT | Acra7 | Cholinergic, Nicotinic Alpha7 | Cholinergic, Nicotinic Alpha7/5-HT3 | Chrna7 | Neuronal acetylcholine receptor | Neuronal acetylcholine receptor (alpha7 nAChR) | Neuronal acetylcholine receptor subunit alpha 7 | Neuronal acetylcholine receptor subunit alpha-7 | Neuronal acetylcholine receptor subunit alpha-7 (nAChR alpha7) | Neuronal acetylcholine receptor subunit alpha-7 (nAChR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 56502.44 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q05941 |
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| Residue: | 502 |
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| Sequence: | MCGGRGGIWLALAAALLHVSLQGEFQRRLYKELVKNYNPLERPVANDSQPLTVYFSLSLL
QIMDVDEKNQVLTTNIWLQMSWTDHYLQWNMSEYPGVKNVRFPDGQIWKPDILLYNSADE
RFDATFHTNVLVNASGHCQYLPPGIFKSSCYIDVRWFPFDVQQCKLKFGSWSYGGWSLDL
QMQEADISSYIPNGEWDLMGIPGKRNEKFYECCKEPYPDVTYTVTMRRRTLYYGLNLLIP
CVLISALALLVFLLPADSGEKISLGITVLLSLTVFMLLVAEIMPATSDSVPLIAQYFAST
MIIVGLSVVVTVIVLRYHHHDPDGGKMPKWTRIILLNWCAWFLRMKRPGEDKVRPACQHK
PRRCSLASVELSAGAGPPTSNGNLLYIGFRGLEGMHCAPTPDSGVVCGRLACSPTHDEHL
MHGAHPSDGDPDLAKILEEVRYIANRFRCQDESEVICSEWKFAACVVDRLCLMAFSVFTI
ICTIGILMSAPNFVEAVSKDFA
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| BDBM50036166 |
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| n/a |
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| Name | BDBM50036166 |
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| Synonyms: | 3-(pyridin-3-yl)-1-azabicyclo[2.2.2]oct-2-ene | 3-Pyridin-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHEMBL64779 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H14N2 |
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| Mol. Mass. | 186.253 |
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| SMILES | C1CN2CCC1C(=C2)c1cccnc1 |c:7,THB:8:6:4.3:0.1,(-3.23,-2.16,;-4,-3.38,;-2.35,-2.5,;-2.35,-1.13,;-1.52,-.29,;-1.51,-1.39,;.03,-2.32,;-.76,-3.46,;1.54,-2,;2.57,-3.14,;4.08,-2.83,;4.56,-1.36,;3.52,-.21,;2.01,-.52,)| |
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| Structure | 
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