| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity protein kinase CLK3 |
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| Ligand | BDBM50302986 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_596747 (CHEMBL1039035) |
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| Kd | 470±n/a nM |
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| Citation |  Mott, BT; Tanega, C; Shen, M; Maloney, DJ; Shinn, P; Leister, W; Marugan, JJ; Inglese, J; Austin, CP; Misteli, T; Auld, DS; Thomas, CJ Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk). Bioorg Med Chem Lett19:6700-5 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity protein kinase CLK3 |
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| Name: | Dual specificity protein kinase CLK3 |
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| Synonyms: | CDC2-like kinase 3 (CLK3) | CLK3 | CLK3_HUMAN | Dual specificity protein kinase CLK3 |
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| Type: | Protein |
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| Mol. Mass.: | 73570.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 638 |
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| Sequence: | MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGG
GPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGL
PRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEG
RLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHR
RRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWL
QERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKD
KENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALR
FLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHT
TIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGP
IPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRM
LEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR
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| BDBM50302986 |
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| n/a |
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| Name | BDBM50302986 |
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| Synonyms: | 6-(benzo[d][1,3]dioxol-5-yl)-N-(thiophen-2-ylmethyl)quinazolin-4-amine | CHEMBL567331 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15N3O2S |
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| Mol. Mass. | 361.417 |
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| SMILES | C(Nc1ncnc2ccc(cc12)-c1ccc2OCOc2c1)c1cccs1 |
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| Structure | 
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