Reaction Details |
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Target | Dual specificity protein phosphatase 3 |
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Ligand | BDBM50303184 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_595099 (CHEMBL1047959) |
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Ki | 3190±n/a nM |
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Citation | Wu, S; Vossius, S; Rahmouni, S; Miletic, AV; Vang, T; Vazquez-Rodriguez, J; Cerignoli, F; Arimura, Y; Williams, S; Hayes, T; Moutschen, M; Vasile, S; Pellecchia, M; Mustelin, T; Tautz, L Multidentate small-molecule inhibitors of vaccinia H1-related (VHR) phosphatase decrease proliferation of cervix cancer cells. J Med Chem52:6716-23 (2009) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dual specificity protein phosphatase 3 |
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Name: | Dual specificity protein phosphatase 3 |
Synonyms: | DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR |
Type: | Hydrolase |
Mol. Mass.: | 20480.58 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 185 |
Sequence: | MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVL
NAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRV
LVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKE
GKLKP
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BDBM50303184 |
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n/a |
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Name | BDBM50303184 |
Synonyms: | 5-((5-(2-bromo-4,5-dimethylphenyl)furan-2-yl)methylene)-2-thioxoimidazolidin-4-one | CHEMBL566634 |
Type | Small organic molecule |
Emp. Form. | C16H13BrN2O2S |
Mol. Mass. | 377.256 |
SMILES | Cc1cc(Br)c(cc1C)-c1ccc(\C=C2/NC(=S)NC2=O)o1 |
Structure |
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