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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mast/stem cell growth factor receptor Kit | ||
| Ligand | BDBM50303224 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_595126 (CHEMBL1050613) | ||
| IC50 | 491±n/a nM | ||
| Citation |  Antczak, C; Veach, DR; Ramirez, CN; Minchenko, MA; Shum, D; Calder, PA; Frattini, MG; Clarkson, B; Djaballah, H Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett19:6872-6 (2009) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mast/stem cell growth factor receptor Kit | |||
| Name: | Mast/stem cell growth factor receptor Kit | ||
| Synonyms: | CD117 antigen | CD_antigen=CD117 | KIT | KIT_HUMAN | Mast/stem cell growth factor receptor Kit (cKIT) | Proto-oncogene c-Kit | Proto-oncogene tyrosine-protein kinase Kit | SCFR | Stem cell growth factor receptor | Tyrosine Kinase c-Kit | Tyrosine-protein kinase Kit | Tyrosine-protein kinase Kit (c-Kit) | c-kit | p-145 c-kit | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | ||
| Type: | Protein | ||
| Mol. Mass.: | 109869.37 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P10721 | ||
| Residue: | 976 | ||
| Sequence: |
| ||
| BDBM50303224 | |||
| n/a | |||
| Name | BDBM50303224 | ||
| Synonyms: | 2-(4-aminophenylamino)-6-(2,6-dichlorophenyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one | CHEMBL566636 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H15Cl2N5O | ||
| Mol. Mass. | 412.272 | ||
| SMILES | Cn1c2nc(Nc3ccc(N)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(3.54,-27.86,;3.54,-26.32,;2.21,-25.55,;.88,-26.33,;-.44,-25.56,;-1.78,-26.33,;-3.11,-25.56,;-4.45,-26.33,;-5.78,-25.56,;-5.78,-24.02,;-7.12,-23.25,;-4.45,-23.25,;-3.12,-24.01,;-.46,-24.02,;.87,-23.25,;2.21,-24.01,;3.54,-23.24,;4.87,-24.01,;6.19,-23.23,;6.19,-21.7,;4.85,-20.94,;7.51,-20.92,;8.86,-21.69,;8.86,-23.23,;7.53,-24,;7.54,-25.54,;4.88,-25.55,;6.21,-26.32,)| | ||
| Structure | 
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