Ki Summary

Reaction Details

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Target

Proto-oncogene tyrosine-protein kinase Src

Ligand

BDBM50303228

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_595125 (CHEMBL1050612)

IC50

213±n/a nM

Citation

Antczak, C; Veach, DR; Ramirez, CN; Minchenko, MA; Shum, D; Calder, PA; Frattini, MG; Clarkson, B; Djaballah, H Structure-activity relationships of 6-(2,6-dichlorophenyl)-8-methyl-2-(phenylamino)pyrido[2,3-d]pyrimidin-7-ones: toward selective Abl inhibitors. Bioorg Med Chem Lett19:6872-6 (2009) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Proto-oncogene tyrosine-protein kinase Src

Name:

Proto-oncogene tyrosine-protein kinase Src

Synonyms:

Type:

Protein

Mol. Mass.:

59838.60

Organism:

Homo sapiens (Human)

Description:

P12931

Residue:

536

Sequence:

MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAE
PKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGD
WWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRES
ETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGL
CHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTL
KPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKY
LRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYT
ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVER
GYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL

BDBM50303228

n/a

Name

BDBM50303228

Synonyms:

CHEMBL565609 | tert-butyl 3-(4-(6-(2,6-dichlorophenyl)-8-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-ylamino)phenylamino)-3-oxopropylcarbamate

Type

Small organic molecule

Emp. Form.

C28H28Cl2N6O4

Mol. Mass.

583.466

SMILES

Cn1c2nc(Nc3ccc(NC(=O)CCNC(=O)OC(C)(C)C)cc3)ncc2cc(-c2c(Cl)cccc2Cl)c1=O |(11.49,-5.91,;11.49,-4.37,;10.16,-3.6,;8.83,-4.37,;7.5,-3.6,;6.17,-4.37,;4.84,-3.6,;3.5,-4.38,;2.17,-3.61,;2.17,-2.06,;.83,-1.29,;-.5,-2.06,;-.5,-3.6,;-1.83,-1.29,;-3.17,-2.06,;-4.5,-1.29,;-5.83,-2.06,;-5.83,-3.6,;-7.17,-1.29,;-8.5,-2.06,;-9.84,-1.29,;-8.5,-3.6,;-9.85,-2.82,;3.5,-1.29,;4.83,-2.05,;7.49,-2.06,;8.82,-1.29,;10.16,-2.06,;11.49,-1.29,;12.82,-2.05,;14.14,-1.28,;14.13,.26,;12.8,1.02,;15.46,1.03,;16.8,.27,;16.81,-1.27,;15.48,-2.05,;15.48,-3.59,;12.83,-3.6,;14.16,-4.36,)|

Structure