| Reaction Details |
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 | Report a problem with these data |
| Target | DNA-(apurinic or apyrimidinic site) endonuclease |
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| Ligand | BDBM50303972 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_595225 (CHEMBL1043577) |
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| IC50 | 1000±n/a nM |
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| Citation |  Nyland, RL; Luo, M; Kelley, MR; Borch, RF Design and synthesis of novel quinone inhibitors targeted to the redox function of apurinic/apyrimidinic endonuclease 1/redox enhancing factor-1 (Ape1/ref-1). J Med Chem53:1200-10 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA-(apurinic or apyrimidinic site) endonuclease |
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| Name: | DNA-(apurinic or apyrimidinic site) endonuclease |
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| Synonyms: | APE | APE1 | APEX | APEX1 | APEX1_HUMAN | APX | Apurinic-apyrimidinic endonuclease 1 (APE-1) | Apurinic/apyrimidinic endonuclease 1 (APE1) | DNA-(apurinic or apyrimidinic site) lyase | HAP1 | REF1 |
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| Type: | Protein |
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| Mol. Mass.: | 35560.12 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P27695 |
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| Residue: | 318 |
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| Sequence: | MPKRGKKGAVAEDGDELRTEPEAKKSKTAAKKNDKEAAGEGPALYEDPPDQKTSPSGKPA
TLKICSWNVDGLRAWIKKKGLDWVKEEAPDILCLQETKCSENKLPAELQELPGLSHQYWS
APSDKEGYSGVGLLSRQCPLKVSYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLV
RLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQERQGF
GELLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLLPALCDSKI
RSKALGSDHCPITLYLAL
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| BDBM50303972 |
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| n/a |
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| Name | BDBM50303972 |
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| Synonyms: | (E)-3-(3-Bromo-1,4-naphthoquinon-2-yl)-2-methoxyethylpropenoic Acid | CHEMBL570293 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13BrO5 |
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| Mol. Mass. | 365.175 |
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| SMILES | COCC\C(=C/C1=C(Br)C(=O)c2ccccc2C1=O)C(O)=O |c:6| |
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| Structure | 
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