| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50304495 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_603857 (CHEMBL1046474) |
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| Ki | 0.36±n/a nM |
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| Citation |  Höltke, C; Law, MP; Wagner, S; Kopka, K; Faust, A; Breyholz, HJ; Schober, O; Bremer, C; Riemann, B; Schäfers, M PET-compatible endothelin receptor radioligands: synthesis and first in vitro and in vivo studies. Bioorg Med Chem17:7197-208 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA_MOUSE | Ednra | Endothelin receptor ET-A | Gpcr10 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48591.87 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_723169 |
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| Residue: | 427 |
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| Sequence: | MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERS
SHKDSMN
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| BDBM50304495 |
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| n/a |
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| Name | BDBM50304495 |
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| Synonyms: | 2-{4-[4-(Benzo[1,3]dioxol-5-yl)-2-hydroxy-5-oxo-3-(3,4,5-trimethoxybenzyl)-2,5-dihydro-furan-2-yl]phenoxy}ethyl 4-methylbenzenesulfonate | CHEMBL611626 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H34O12S |
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| Mol. Mass. | 690.713 |
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| SMILES | COc1cc(CC2=C(C(=O)OC2(O)c2ccc(OCCOc3ccc(cc3)S(C)(=O)=O)cc2)c2ccc3OCOc3c2)cc(OC)c1OC |t:6| |
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| Structure | 
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