| Reaction Details |
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 | Report a problem with these data |
| Target | Endothelin-1 receptor |
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| Ligand | BDBM50304497 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_603857 (CHEMBL1046474) |
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| Ki | 1.26±n/a nM |
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| Citation |  Höltke, C; Law, MP; Wagner, S; Kopka, K; Faust, A; Breyholz, HJ; Schober, O; Bremer, C; Riemann, B; Schäfers, M PET-compatible endothelin receptor radioligands: synthesis and first in vitro and in vivo studies. Bioorg Med Chem17:7197-208 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Endothelin-1 receptor |
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| Name: | Endothelin-1 receptor |
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| Synonyms: | EDNRA_MOUSE | Ednra | Endothelin receptor ET-A | Gpcr10 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48591.87 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_723169 |
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| Residue: | 427 |
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| Sequence: | MSIFCLAAYFWLTMVGGVMADNPERYSANLSSHMEDFTPFPGTEINFLGTTHRPPNLALP
SNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIA
SLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALS
VDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGELHRTCM
LNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQ
RREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATM
NSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNNHNTERS
SHKDSMN
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| BDBM50304497 |
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| n/a |
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| Name | BDBM50304497 |
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| Synonyms: | 2-(5-{[4-(Benzo[1,3]dioxol-5-yl)-2-hydroxy-2-(4-methoxyphenyl)-5-oxo-2,5-dihydrofuran-3-yl]methyl}-2,3-dimethoxyphenoxy)ethyl 4-methylbenzenesulfonate | CHEMBL593928 |
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| Type | Small organic molecule |
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| Emp. Form. | C36H34O12S |
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| Mol. Mass. | 690.713 |
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| SMILES | COc1ccc(cc1)C1(O)OC(=O)C(=C1Cc1cc(OC)c(OC)c(OCCOc2ccc(cc2)S(C)(=O)=O)c1)c1ccc2OCOc2c1 |c:14| |
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| Structure | 
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