| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIF11 |
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| Ligand | BDBM50305223 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_603302 (CHEMBL1037992) |
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| IC50 | 2500±n/a nM |
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| Citation |  Barsanti, PA; Wang, W; Ni, ZJ; Duhl, D; Brammeier, N; Martin, E; Bussiere, D; Walter, AO The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5. Bioorg Med Chem Lett20:157-60 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin-like protein KIF11 |
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| Name: | Kinesin-like protein KIF11 |
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| Synonyms: | EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin Spindle Protein Eg5 | Kinesin-like protein 1 | TRIP5 | kinesin spindle protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 119138.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1457426 |
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| Residue: | 1056 |
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| Sequence: | MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADK
SSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE
RLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS
VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT
ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL
NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV
ELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEY
ITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNS
LFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV
SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKT
SLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQ
ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS
QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNER
EQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE
TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLM
MLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGK
DKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
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| BDBM50305223 |
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| n/a |
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| Name | BDBM50305223 |
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| Synonyms: | 1-(1-(3-hydroxyphenyl)-3,4-dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)ethanone | CHEMBL574446 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18N2O2 |
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| Mol. Mass. | 306.3584 |
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| SMILES | CC(=O)N1CCc2c([nH]c3ccccc23)C1c1cccc(O)c1 |
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| Structure | 
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