| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional epoxide hydrolase 2 |
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| Ligand | BDBM50305635 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_604538 (CHEMBL1074708) |
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| IC50 | 3.9±n/a nM |
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| Citation |  Eldrup, AB; Soleymanzadeh, F; Farrow, NA; Kukulka, A; De Lombaert, S Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase. Bioorg Med Chem Lett20:571-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional epoxide hydrolase 2 |
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| Name: | Bifunctional epoxide hydrolase 2 |
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| Synonyms: | Cytosolic epoxide hydrolase 2 | EBifunctional epoxide hydrolase 2 | EPHX2 | Epoxide hydratase | HYES_HUMAN | Lipid-phosphate phosphatase | Soluble epoxide hydrolase (sEH) | epoxide hydrolase 2, cytoplasmic |
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| Type: | Enzyme |
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| Mol. Mass.: | 62613.07 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P34913 |
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| Residue: | 555 |
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| Sequence: | MTLRAAVFDLDGVLALPAVFGVLGRTEEALALPRGLLNDAFQKGGPEGATTRLMKGEITL
SQWIPLMEENCRKCSETAKVCLPKNFSIKEIFDKAISARKINRPMLQAALMLRKKGFTTA
ILTNTWLDDRAERDGLAQLMCELKMHFDFLIESCQVGMVKPEPQIYKFLLDTLKASPSEV
VFLDDIGANLKPARDLGMVTILVQDTDTALKELEKVTGIQLLNTPAPLPTSCNPSDMSHG
YVTVKPRVRLHFVELGSGPAVCLCHGFPESWYSWRYQIPALAQAGYRVLAMDMKGYGESS
APPEIEEYCMEVLCKEMVTFLDKLGLSQAVFIGHDWGGMLVWYMALFYPERVRAVASLNT
PFIPANPNMSPLESIKANPVFDYQLYFQEPGVAEAELEQNLSRTFKSLFRASDESVLSMH
KVCEAGGLFVNSPEEPSLSRMVTEEEIQFYVQQFKKSGFRGPLNWYRNMERNWKWACKSL
GRKILIPALMVTAEKDFVLVPQMSQHMEDWIPHLKRGHIEDCGHWTQMDKPTEVNQILIK
WLDSDARNPPVVSKM
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| BDBM50305635 |
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| n/a |
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| Name | BDBM50305635 |
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| Synonyms: | 4-(2-cyanophenoxy)-N-(2,4-dichlorobenzyl)piperidine-1-carboxamide | CHEMBL589376 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19Cl2N3O2 |
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| Mol. Mass. | 404.29 |
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| SMILES | Clc1ccc(CNC(=O)N2CCC(CC2)Oc2ccccc2C#N)c(Cl)c1 |
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| Structure | 
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