Reaction Details |
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Target | C5a anaphylatoxin chemotactic receptor 1 |
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Ligand | BDBM50305731 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_604751 (CHEMBL1072545) |
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IC50 | 400±n/a nM |
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Citation | Chen, JJ; Cole, DC; Ciszewski, G; Crouse, K; Ellingboe, JW; Nowak, P; Tawa, GJ; Berstein, G; Li, W Identification of a new class of small molecule C5a receptor antagonists. Bioorg Med Chem Lett20:662-4 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C5a anaphylatoxin chemotactic receptor 1 |
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Name: | C5a anaphylatoxin chemotactic receptor 1 |
Synonyms: | C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88 |
Type: | Enzyme |
Mol. Mass.: | 39347.68 |
Organism: | Homo sapiens (Human) |
Description: | P21730 |
Residue: | 350 |
Sequence: | MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
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BDBM50305731 |
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n/a |
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Name | BDBM50305731 |
Synonyms: | CHEMBL604583 | N,4-dimethyl-N-(2-(thiophene-3-carbonyl)phenyl)benzenesulfonamide |
Type | Small organic molecule |
Emp. Form. | C19H17NO3S2 |
Mol. Mass. | 371.473 |
SMILES | CN(c1ccccc1C(=O)c1ccsc1)S(=O)(=O)c1ccc(C)cc1 |
Structure |
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