Reaction Details |
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Target | Muscarinic acetylcholine receptor M3 |
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Ligand | BDBM50258723 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_605046 (CHEMBL1071908) |
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EC50 | 2200±n/a nM |
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Citation | Bridges, TM; Kennedy, JP; Cho, HP; Breininger, ML; Gentry, PR; Hopkins, CR; Conn, PJ; Lindsley, CW Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett20:558-62 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Muscarinic acetylcholine receptor M3 |
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Name: | Muscarinic acetylcholine receptor M3 |
Synonyms: | ACM3_HUMAN | CHRM3 | Cholinergic, muscarinic M3 | Muscarinic Receptors M3 | Muscarinic receptor M3 | RecName: Full=Muscarinic acetylcholine receptor M3 |
Type: | Enzyme |
Mol. Mass.: | 66151.03 |
Organism: | Homo sapiens (Human) |
Description: | P20309 |
Residue: | 590 |
Sequence: | MTLHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPL
GGHTVWQVVFIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIGVI
SMNLFTTYIIMNRWALGNLACDLWLAIDYVASNASVMNLLVISFDRYFSITRPLTYRAKR
TTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAF
YMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSM
KRSNRRKYGRCHFWFTTKSWKPSSEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSE
TRAIYSIVLKLPGHSTILNSTKLPSSDNLQVPEEELGMVDLERKADKLQAQKSVDDGGSF
PKSFSKLPIQLESAVDTAKTSDVNSSVGKSTATLPLSFKEATLAKRFALKTRSQITKRKR
MSLVKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTFWNLGYWLCYINSTVN
PVCYALCNKTFRTTFKMLLLCQCDKKKRRKQQYQQRQSVIFHKRAPEQAL
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BDBM50258723 |
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n/a |
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Name | BDBM50258723 |
Synonyms: | 7-chloro-1-(4-(trifluoromethyl)benzyl)indoline-2,3-dione | CHEMBL503735 |
Type | Small organic molecule |
Emp. Form. | C16H9ClF3NO2 |
Mol. Mass. | 339.696 |
SMILES | FC(F)(F)c1ccc(CN2C(=O)C(=O)c3cccc(Cl)c23)cc1 |
Structure |
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