Ki Summary

Reaction Details

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Target

Peroxisome proliferator-activated receptor gamma

Ligand

BDBM50085048

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_610592 (CHEMBL1069606)

EC50

13±n/a nM

Citation

Lamotte, Y; Martres, P; Faucher, N; Laroze, A; Grillot, D; Ancellin, N; Saintillan, Y; Beneton, V; Gampe, RT Synthesis and biological activities of novel indole derivatives as potent and selective PPARgamma modulators. Bioorg Med Chem Lett20:1399-404 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Peroxisome proliferator-activated receptor gamma

Name:

Peroxisome proliferator-activated receptor gamma

Synonyms:

Nr1c3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG_MOUSE | Pparg

Type:

PROTEIN

Mol. Mass.:

57593.55

Organism:

Mus musculus

Description:

ChEMBL_1453700

Residue:

505

Sequence:

MGETLGDSPVDPEHGAFADALPMSTSQEITMVDTEMPFWPTNFGISSVDLSVMEDHSHSF
DIKPFTTVDFSSISAPHYEDIPFTRADPMVADYKYDLKLQEYQSAIKVEPASPPYYSEKT
QLYNRPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNC
RIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLR
ALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQE
QSKEVAIRIFQGCQFRSVEAVQEITEYAKNIPGFINLDLNDQVTLLKYGVHEIIYTMLAS
LMNKDGVLISEGQGFMTREFLKNLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVII
LSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKVLQKMTDLRQIVTEHVQL
LHVIKKTETDMSLHPLLQEIYKDLY

BDBM50085048

n/a

Name

BDBM50085048

Synonyms:

(S)-2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyridin-2-yl-amino)-ethoxy]-phenyl}-propionic acid | (S)-2-(2-benzoylphenylamino)-3-(4-(2-(methyl(pyridin-2-yl)amino)ethoxy)phenyl)propanoic acid | 2-(2-Benzoyl-phenylamino)-3-{4-[2-(methyl-pyridin-2-yl-amino)-ethoxy]-phenyl}-propionic acid | CHEMBL434063

Type

Small organic molecule

Emp. Form.

C30H29N3O4

Mol. Mass.

495.569

SMILES

CN(CCOc1ccc(C[C@H](Nc2ccccc2C(=O)c2ccccc2)C(O)=O)cc1)c1ccccn1

Structure