| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 1 |
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| Ligand | BDBM50107130 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_610767 (CHEMBL1064402) |
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| Ki | 8700±n/a nM |
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| Citation |  Bernardo, PH; Sivaraman, T; Wan, KF; Xu, J; Krishnamoorthy, J; Song, CM; Tian, L; Chin, JS; Lim, DS; Mok, HY; Yu, VC; Tong, JC; Chai, CL Structural insights into the design of small molecule inhibitors that selectively antagonize Mcl-1. J Med Chem53:2314-8 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 1 |
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| Name: | Bcl-2-like protein 1 |
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| Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
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| Type: | Mitochondrion membrane; Single-pass membrane protein |
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| Mol. Mass.: | 26039.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM50107130 |
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| n/a |
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| Name | BDBM50107130 |
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| Synonyms: | (Z)-2-(5-(4-bromobenzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-methylbutanoic acid | 2-[5-(4-Bromo-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-3-methyl-butyric acid | CHEMBL335265 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14BrNO3S2 |
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| Mol. Mass. | 400.311 |
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| SMILES | CC(C)C(N1C(=S)S\C(=C/c2ccc(Br)cc2)C1=O)C(O)=O |
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| Structure | 
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